Research Overview

My research focuses on elucidating the functional roles of microorganisms in host health and disease, with an emphasis on translational applications and mechanistic insights.

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1. Discovery and Functional Validation of Beneficial Microbes in Mammalian Models
I identify and characterize beneficial microbial strains using mammalian systems. Their protective efficacy is rigorously evaluated in disease contexts, particularly in sepsis infection models, to establish causal relationships between microbial function and host survival.

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2. Identification of Preventive and Therapeutic Candidates and Mechanistic Dissection
I screen and develop candidate molecules with prophylactic and therapeutic potential. Using sepsis models, I investigate the underlying immunological mechanisms, focusing on host–microbe interactions, immune modulation, and pathways governing systemic inflammation.

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3. Animal–Microbe Symbioses
I study the fundamental principles of symbiotic relationships between animals and their associated microorganisms, aiming to understand how these interactions shape host physiology, immunity, and evolutionary adaptation.

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4. Microbiome Research from an Ecological Perspective
I integrate microbial ecology with host biology to examine microbiome structure, dynamics, and function. My work explores how ecological principles, such as community assembly, competition, and resilience, govern host-associated microbial ecosystems.

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Through these approaches, I aim to bridge fundamental microbiology with translational immunology, advancing microbiome-based strategies for disease prevention and treatment.